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diagnosis differential liver transaminitis injury aih anticoagulation autoimmune causes chemistry coronavirus covid19 criticalcare empiric enzymes hepatocellular interpretation liverenzymes liverfunctiontests rvalue
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... - Ischemic Hepatitis ... AST:ALT > 2.5 - Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Hepatocellular Pattern ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
hepatocellular pattern ... though cholestatic pattern ... IgG typically elevated ... upper limit of normal ... #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... ALT Ratios: • Alcoholic ... #differential #Hepatology ... transaminitis #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... evaluation of the pattern ... dehydrogenase; NAFLD, non-alcoholic ... #LFTs #Abnormal ... #Algorithm #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... specificity to elevated ... function may be abnormal ... ALT Ratios: • Alcoholic ... #hepatology
Possible approach to empiric anticoagulation in COVID-19 Is D-dimer above '"1,000-2,000 ng/ml? Contraindication to anticoagulation? Check fibrinogen level and/or
or elevated Hypo-coagulable ... pattern (rare, ... anticoagulation #COVID19 #management ... #schema #criticalcare ... #algorithm #SARSCOV2
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