20 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... 20x normal - Acute ... #Patterns #Liver ... #Injury #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... injury - Viral ... Hepatitis - Autoimmune ... #Differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... HSV • Toxic: Alcohol ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
HEV, EBV, CMV), Alcohol-related ... Hepatic ischaemia ... dechallenge • Acute ... steatosis • Autoimmune ... #Algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Autoimmune ... hepatitis • Drugs ... Others #LFTs #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Chronic Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... HepatitisAutoimmune ... #Causes #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... : Autoimmune hepatitis ... ALT Ratios: • Alcoholic ... #injury #hepatitis ... #hepatology