11 results
diagnosis differential liver transaminitis injury management abnormal aclf albumin ascites causes chemistry chronic dili druginduced elevated failure function gastroenterology gradient
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
20x normal - Acute ... cirrhosis, Portal ... AST:ALT > 2.5 - Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... hepatitis • Drugs ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... • NAFLD • Cirrhosis ... Hepatopathy • Acute ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... #Hepatology #gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... ALT Ratios: • Alcoholic ... : < 1 • Cirrhosis ... #differential #Hepatology ... transaminitis #LFTs
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
>1.1 g/dl): - Cirrhosis ... - Alcoholic hepatitis ... Veno-occlusive disease - Acute ... associated with bowel ischemia ... Differential #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... ALT Ratios: • Alcoholic ... : < 1 • Cirrhosis ... differential #diagnosis #algorithm ... #hepatology
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