19 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... , HBV, HCV, HEV, ... hepatitis fibrosis ... • Autoimmune hepatitis ... #Liver #Injury
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
, HCV, HEV, EBV, ... Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
: HAV, HBV, HCV, ... HEV, EBV, HSV, ... Autoimmune: Autoimmune hepatitis ... viral hepatitis ... #injury #hepatitis
Interpretation of Hepatitis B Serologies 
HBsAg - HBcAb (total) - HBcAb (IgM) - HBsAb
Susceptible to HBV
Immune
Interpretation of Hepatitis ... Chronic HBV Resolved ... BrighamChiefs #HepatitisB ... serology #diagnosis #hepatology ... interpreation #testing
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... 5-10x normal - Chronic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Cirrhosis • Chronic ... Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... injury (INR > 2 ... mg/dL) or acute liver ... failure #HepatitisB ... Indications #management #hepatology
Hepatitis B Disease Progression Timeline
 • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... HBV-infected individuals ... of chronic HBV-infected ... developing cirrhosis #HepatitisB ... Epidemiology #HepB #HBV
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... • Infections: Hepatitis ... CMV, HSV, VZV ... • Vascular: Ischemic ... #LFTs #hepatitis