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diagnosis differential injury lfts causes transaminitis chemistry dili druginduced eosinophilia hematology interpretation liverenzymes management patterns rvalue
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... dechallenge • Acute ... steatosis • Autoimmune ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Diagnosis Hepatocellular ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... Celiac Disease Hepatocellular ... #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Acute Liver Injury ... , HBV, HCV, HEV, ... : Autoimmune hepatitis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... 5-10x normal - Chronic ... #Injury #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... subclinical disease to acute ... - Symptoms of chronic ... - Typically hepatocellular ... #Hepatitis #AIH
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Autoimmune ... • Drugs • AIH ... • Alcoholic hepatitis
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- DRESS - AIN ... - Eosinophilic Hepatitis ... (vasculitis / autoimmune ... Mastocytosis - Acute ... Hypereosinophilic Syndrome - Chronic
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