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diagnosis differential injury lfts transaminitis causes management acute chemistry common cvid druginduced elevated fatigue function hematology hepatitisb hepatocellular hypogammaglobulinemia immunodeficiency
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... steatosis • Autoimmune ... hepatitis #DILI ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... obstruction syndrome • Autoimmune ... : DILI, Tylenol, ... See Updated Schema ... Diagnosis #causes #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV ... Management #Treatment #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... , HBV, HCV, HEV, ... : Autoimmune hepatitis ... • Iatrogenic: DILI ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Infection (EBV ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
C, A, E, B, D, EBV ... , CMV, HSV • Toxic ... Other: NAFLD, Autoimmune ... Causes #Acute #algorithm ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Autoimmune ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
serologies, HCV ... > 2 • NASH, Chronic ... viral hepatitis ... injury: > 3 • Chronic ... #differential #Hepatology
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