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diagnosis differential injury hematology lfts interpretation transaminitis cvid diffuse dili druginduced gap globulin hepatitisb hypogammaglobulinemia immunodeficiency immunology laboratory lad liverenzymes
Hepatitis B Virus Serology and Interpretation HBsAg - Anti-HBs - Anti-HBc - HBeAg - Anti-HBe - Acute
Acute hepatitis ... B - Chronic hepatitis ... ) - Acute hepatitis ... False-positive; less commonly ... diagnosis #laboratory #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... , HBV, HCV, HEV, ... Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... 5-10x normal - Chronic ... #Injury #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... , Acute biliary ... Differential #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... of Acute Liver ... , HBV, HCV, HEV, ... #hepatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Tuberculosis • Hepatitis ... Fatigue • Acute ... Age > 50 • Chronic ... #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #chemistry #diagnosis ... #differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Bile Ducts • Common ... #Causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... disease • Liver ... diseases and hepatitis ... DDX - Other causes ... Malignancies • Chronic
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Viral infections (acute ... HIV, HBV, EBV, ... Sarcoidosis) • Liver ... inflammation (acute ... Comment on type
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