14 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Hepatic ischaemia ... hepatitis fibrosis ... • Autoimmune hepatitis ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #HepatitisB #HBV
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... , Toxic Hepatitis ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
• NAFLD • Cirrhosis ... • Chronic Viral ... Hepatitis Moderate ... • Acute Viral Hepatitis ... (>1000): • DILI
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis ... #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... viral hepatitis ... : < 1 • Cirrhosis ... #injury #hepatitis ... #hepatology
Hepatitis B Disease Progression Timeline
 • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... develop Liver Cancer ... develop cirrhosis ... #HepatitisB #Disease ... Timeline #Prognosis #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Differential Diagnosis Chronic ... liver disease ( ... cirrhosis or chronic ... hepatitis) - 80% ... Differential #Diagnosis #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Liver disease ... - Cirrhosis ... - Alcoholic hepatitis ... - Acute fatty liver ... #differential #hepatology