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diagnosis transaminitis injury causes abnormal chemistry dili druginduced function hepatocellular interpretation liverenzymes liverfunctiontests patterns rvalue tests transaminases
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... Cirrhosis • Chronic ... injury) • Ischemic ... Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Transaminitis - Differential ... Trauma: Shock liver ... See Updated Schema ... Diagnosis #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... disorder (e.g. ascites ... ), Chronic hepatitis ... #hepatology
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Ascites - Differential ... Diagnosis Chronic ... liver disease ( ... hepatitis) - 80% ... Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... , HBV, HCV, HEV, ... specificity to elevated ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #Elevated #Abnormal
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