16 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... EBV, CMV), Alcohol-related ... ascites), Chronic hepatitis ... hepatitis #DILI ... #Algorithm #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Trauma: Shock liver ... hepatitis • Iatrogenic ... : DILI, Tylenol, ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... Hepatitis AST ... #Injury #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
: Autoimmune hepatitis ... • Iatrogenic: DILI ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... hepatitis, Acute ... Hepatitis, TPN ... Sepsis, Viral Hepatitis ... #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic ... hepatitis - Acute ... Hepatitis - Autoimmune ... hepatitis - ... #Differential #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... • Infections: Hepatitis ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #LFTs #hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Infectious • Hepatitis ... HepatitisAutoimmune ... Hepatitis • Drug ... Induced Hepatitis ... #Causes #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology