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diagnosis lfts transaminitis causes acute management alcoholic chemistry chronic cirrhosis druginduced elevated failure function gastroenterology hepatocellular interpretation liverenzymes liverinjury patterns
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... , HBV, HCV, HEV, ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #Liver #Injury
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... #Injury #hepatology ... transaminitis #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) ... Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... • Iatrogenic: DILI ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Injury - Ichemic ... hepatitis - Acute ... Hepatitis - Autoimmune ... hepatitis - ... #Hepatology #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury Differential ... • Infections: Hepatitis ... #Injury #Differential ... #LFTs #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... • Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Sepsis, Viral Hepatitis ... #Injury #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... • Liver injury ... Chronic viral hepatitis ... #Hepatology #transaminitis
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