19 results
Hepatitis B Management in Cancer

DOI: 10.1200/JCO.20.01757

#HepatitisB #HBV #HepBV #Management #Cancer #oncology #hepatology #algorithm
Hepatitis B Management ... JCO.20.01757 #HepatitisB ... #HBV #HepBV #Management ... Cancer #oncology #hepatology ... #algorithm
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... AST:ALT = 1 - Ischemia ... #hepatology #LFTs
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
, HCV, HEV, EBV, ... • Autoimmune hepatitis ... See Updated Schema ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... Chronic Hepatitis ... .2018.3795 #Chronic #HepatitisB ... #HBV #Algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... disease, Hepatic ischaemia ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #hepatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... with severe liver injury ... liver failure #HepatitisB ... #Indications #management ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis ... #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
• Early acute hepatitis ... • Ischemic hepatitis ... hepatitis (ALT-to-LDH ... 1.5) from viral hepatitis ... • Demand ischemia
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
, HBV, HCV, HEV, ... Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... #hepatitis #differential ... #hepatology