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diagnosis liver differential injury dili transaminitis abnormal aclf acute causes chronic cirrhosis druginduced elevated failure hepatocellular idiosyncratic induced liverenzymes liverfunctiontests
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
/Toxins • Ischemia ... • NAFLD • Alcohol ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... 15X ULN - Drugs ... , Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... #algorithm #gastroenterology ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
valproate, azoles), Drugs ... (MDMA), Alcohol ... • Vascular: Ischemic ... #algorithm #Transaminitis ... #LFTs #hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Drug-Induced Liver ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... • Autoimmune hepatitis ... #hepatology
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