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diagnosis differential liver causes transaminitis management aclf aih alcoholic autoimmune chemistry cirrhosis dehydrogenase dili druginduced emesis failure function gastroenterology hepatocellular
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Hepatitis > ... 20x normal - Acute ... Viral Hepatitis ... 5-10x normal - Chronic ... #hepatology #LFTs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
- Ichemic hepatitis ... - Viral Hepatitis ... - Autoimmune hepatitis ... - Wilson disease ... #Differential #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, Hepatic ischaemia ... dechallenge • Acute ... hepatitis fibrosis ... • Autoimmune hepatitis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... specificity to elevated ... viral hepatitis ... #differential #Hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
: • Early acute ... hepatitis • Ischemic ... hepatitis • Acute ... hepatitis (ALT-to-LDH ... 1.5) from viral hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... underlying liver disease ... Alcohol-Associated Hepatitis ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis
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