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diagnosis differential liver transaminitis causes acute aih chemistry dili druginduced function hepatocellular interpretation liverenzymes liverinjury management patterns rvalue severe tests
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... normal - Chronic hepatitis ... #hepatology #LFTs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... Drug-induced liver injury ... ) • Ischemic Hepatopathy
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
- Ichemic hepatitis ... - Viral Hepatitis ... - Autoimmune ... hepatitis - Wilson ... #Differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Autoimmune ... • Alcoholic hepatitis ... • Others #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Other: NAFLD, Autoimmune ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... obstruction syndrome • Autoimmune ... hepatitis • Iatrogenic ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... hepatitis, Acute ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ischaemia ... ascites), Chronic hepatitis ... steatosis • Autoimmune ... hepatitis #DILI ... #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... pattern of liver injury ... IgG typically elevated ... Other Etiology of Hepatitis ... #Hepatitis #AIH
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
: Autoimmune hepatitis ... specificity to elevated ... Chronic viral hepatitis ... #hepatitis #differential ... #hepatology
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