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differential ascites gradient injury laboratory acutephasereactants causes chemistry dili druginduced hepatic hepatitis hypertension interpretation lfts liverfailure pathophysiology portal rvalue serum
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
Diagnosis of ascites ... serum ascites albumin ... syndrome, Massive liver ... #gradient #hepatology ... #algorithm
Ascites - Differential Diagnosis and Workup Algorithm • Perform paracentesis: • Cell count and diff • Total
- Differential Diagnosis ... and Workup Algorithm ... • Calculate SAAG ... #Algorithm #gastroenterology ... #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Gradient (SAAG) ... - Differential Diagnosis ... Veno-occlusive disease - Acute ... associated with bowel ischemia ... #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
HTN: ascites (SAAG ... Preserved hepatic synthetic ... INR, bilirubin, albumin ... • Cirrhosis/acute ... #causes #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular ... #differential #diagnosis ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
salts augment synthesis ... ALP - Due to synthesis ... Production: • Albumin ... #chemistry #diagnosis ... #differential #Hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Hypoalbuminemia - Decreased albumin ... synthesis - Elevated ... —100-fold with acute ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Acute-phase Reactants Synthesized in the Liver Positive acute-phase reactants (concentrations increase with acute inflammation) - Immune-related
Synthesized in the Liver ... Serum amyloid A (SAA ... Transthyretin (TBPA) - Albumin ... #Synthesized #Liver ... #Synthesis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Algorithm #hepatology
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