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diagnosis differential lfts injury transaminitis causes disease fatty fattyliver management progression timeline abnormal acute albumin ascites biopsy chemistry chronic dili
NAFLD / NASH Progression Timeline Healthy Liver → NAFLD/NASH → 0.25-3.2%/year → Cirrhotic NASH → 0.3-2.6%/year →
NAFLD / NASH Progression ... Timeline Healthy Liver ... → NAFLD/NASH → ... /NASH → Cirrhotic ... #Timeline #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... normal - Hemolysis, NASH ... #Patterns #Liver ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
100-500): • NAFLD ... • Cirrhosis ... Chronic Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
NAFLD Diagnosis Algorithm Two-step diagnostic strategy for NAFLD 1st step: - Clinical biomarkers, scoring systems- FIB4,
Algorithm Two-step ... inspection of liver ... elastography #NonAlcoholic ... #Fatty #Liver # ... #hepatology #NASH
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Hemochromatosis - Nonalcoholic ... fatty liver disease ... #Differential #Hepatology
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 NASH/NAFLD - Liver Biopsy Indications Algorithm #NASH #NAFLD #Liver #Biopsy #Indications #Algorithm #diagnosis #hepatology
NASH/NAFLD - Liver ... #NASH #NAFLD ... #Liver #Biopsy ... #Indications #Algorithm ... #diagnosis #hepatology
Non-Alcoholic Fatty Liver Disease (NAFLD) Progression / Prognosis Timeline • 100 patients → (over 20+ years)
Non-Alcoholic Fatty Liver ... Disease (NAFLD) ... Burak @kwburak #NonAlcoholic ... FattyLiver #Disease #NAFLD ... Prognosis #Timeline #Hepatology
Non-Alcoholic Fatty Liver Disease (NAFLD) - Diagnosis Algorithm Low Suspicion: ≤ 1 feature of
Non-Alcoholic Fatty Liver ... Disease (NAFLD) ... - Diagnosis Algorithm ... NFS ≥ -1.455 #NonAlcoholic ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Drugs, Viral, Ischemia ... Wilson's, HH, NAFLD ... Congenital, Others, Cirrhosis ... #diagnosis #hepatology
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