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differential causes lfts transaminitis lactate acidosis classification dehydrogenase dili druginduced elevated elevation function hepatocellular laboratory ldh liverenzymes liverinjury patterns severe
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
100-500): • NAFLD ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic ... #hepatology #transaminitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... injury - Viral ... #Differential #Hepatology ... #Diagnosis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... 20x normal - Acute ... #Injury #hepatology ... #differential #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... Antitrypsin • Other: NAFLD ... #Acute #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... • Vascular: Ischemic ... antitrypsin • Other: NAFLD ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Algorithm Severe ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular ... #injury #hepatitis ... #algorithm #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... RBCs, muscle, liver ... : • Early acute ... hepatitis • Ischemic ... hepatitis • Acute
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
or renal injury ... cardiac output - Acute ... peritonitis - Acute ... 30mmHg) - Severe anemia ... Injury: • Reduced
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