11 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... normal - Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... 100-500): • NAFLD ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... • Vascular: Ischemic ... antitrypsin • Other: NAFLD ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... for Transaminitis ... Drugs, Viral, Ischemia ... Wilson's, HH, NAFLD ... #hepatology #LiverFunctionTests
NASH/NAFLD - Liver Biopsy Indications Algorithm

#NASH #NAFLD #Liver #Biopsy #Indications #Algorithm #diagnosis #hepatology
NASH/NAFLD - Liver ... #NASH #NAFLD ... #Liver #Biopsy ... #Indications #Algorithm ... #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... ALT < 5x ULN • NAFLD ... Others #LFTs #Hepatology
NAFLD Diagnosis Algorithm
Two-step diagnostic strategy for NAFLD
1st step: 
  - Clinical biomarkers, scoring systems- FIB4,
Algorithm Two-step ... inspection of liver ... NonAlcoholic #Fatty #Liver ... #Diagnosis #Algorithm ... #hepatology #NASH
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Antitrypsin • Other: NAFLD ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... involvement, Kidney injury ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
injury < 26 weeks ... hepatocellular injury ... disease: > 2 • NASH ... #differential #Hepatology ... #transaminitis