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diagnosis differential causes transaminitis dili gastroenterology abnormal aclf chronic cirrhosis druginduced elevated failure function hepatitis hepatocellular idiosyncratic induced liverenzymes liverfunctiontests
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
100-500): • NAFLD ... Hepatopathy • Acute ... 1000): • DILI (Drug-induced ... liver injury) ... • Ischemic Hepatopathy
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... /Toxins • Ischemia ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver ... valproate, azoles), Drugs ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #LFTs #hepatitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... obstruction - Drug-Induced ... liver injury ... hepatitis - Wilson disease ... #Differential #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #algorithm ... gastroenterology #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... 15X ULN - Drugs ... , Viral, Ischemia ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... , Recreational Drugs ... Antitrypsin • Other: NAFLD ... #Injury #Differential ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... disease, Hepatic ... ischaemia, Autoantibody ... dechallenge • Acute ... #Algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology
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