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diagnosis oncology treatment differential hepatitis mds myelodysplastic product reactions alcoholic apml cancer classification cvid differentiation encephalopathy essential et gastronintestinal hemophilia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... • Risks: infection ... transformation to acute ... #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Attempt if high risk ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... carries a variable risk ... Most common cytopenia ... and reducing the risk ... #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - ACS, AKI, acute ... limb ischemia, ... TLS #diagnosis #management ... #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
normal in mild cases ... severity Treatment - Acute ... Avoid meds that ... ↑ bleeding risk ... #treatment #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
being the most common ... Risk factors 3. ... , ADEM, Acute toxic ... elevated white blood ... #diagnosis #management
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... vein: Budd-chiari syndrome ... intestines, white blood ... #hepatology
Occult and Lower Gastronintestinal Bleed - Differential Diagnosis Algorithm Occult (Stool + Occult blood and/or iron deficiency
Stool + Occult blood ... Patient • RULE OUT BRISK ... Diverticular bleed, • Acute ... colitis (ischemia ... #Causes
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
(FNHTR): Most common ... • Acute Hemolytic ... Transfusion Related Acute ... Transfusion #diagnosis #management ... #hematology #reactions
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