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diagnosis hematology pediatrics antibiotics febrile hemophagocytic hlh lp lymphohistiocytosis oncology stepbystep stratification apml differential differentiation ebm encephalopathy fungal gout hemeonc
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm Congenital Anomaly / Disorder: •
Causes of Sudden ... Accidental* Other: • Acute ... Death Syndrome ... 80% of SUDI • Risk ... #Causes #Peds #
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... ” an infant with ... #Diagnosis #Management ... #Pediatrics #Peds ... #Febrile #Infant
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... • Risks: infection ... transformation to acute ... #treatment #hematology
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
to identify low-risk ... empiric antibiotic treatment ... Diagnosis #EBM #Management ... #Pediatrics #Peds ... Stratification #Fever
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - 80% have fever ... - ACS, AKI, acute ... limb ischemia, ... TLS #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Attempt if high risk ... : • Common: fever ... APML #diagnosis #management
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
normal in mild cases ... - Acute Bleeding ... Avoid meds that ... ↑ bleeding risk ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... frequently affects infants ... presents as an acute ... following: • Fever ... #treatment #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Risk factors 3. ... , ADEM, Acute toxic ... the underlying cause ... • Treatment of ... #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... , with ensuing ischemia ... Encapsulated yeast • At risk ... Fungal #Diagnosis #Management
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