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diagnosis causes abnormal management prolonged pt aflp arterial bleeding bruising centralretinalartery crao disorders disseminated embolism fatty hemostasis hepatology intravascular obgyn
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... (DIC) c. ... Causes #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... • Severe Liver ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... intravascularcoagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... cases: INR/PT, aPTT ... (liver disease, ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... Warfarin • Acute DIC ... disease • Acute DIC ... #Diagnosis #Hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... rapidly develops (DIC ... infiltration) Differential ... Maternal Support - Critical ... #Pregnancy #hepatology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Pathogenesis and clinical ... ) -> Increased coagulation ... decreased anti-coagulation ... • Hematologic ... Occlusion #CRAO #pathophysiology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Nephrotic Syndrome, Ischemic ... Liver, IBD • ... intravascular coagulation ... Venous #Arterial #pathophysiology ... #hematology #differential
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