31 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... Diagnosis and Workup ... cases: INR/PT, aPTT ... ., SLE), anti-phospholipid ... #hematology
Approach to a Positive (+) Rheumatoid Factor (RF)
(+) RF does not always = RA
Rheumatic disorders:
 •
RA Rheumatic disorders ... arthritis • SLE ... of Liver & Lung ... Rheumatoid #Factor #RF #rheumatology ... #laboratory #differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... , Seizure disorders ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Bleeding / Bruising - Differential ... Sequestration Disordered ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... Associated - SLE ... #Diagnosis #hematology ... #rheumatology #
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... • Reduced liver ... Causes #diagnosis #differential ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... Early liver disease ... Reduced liver synthesis ... Causes #diagnosis #differential ... #hematology #coagulation
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
) • Advanced Liver ... Malignancy, Autoimmune disorders ... (e.g. ... RA, SLE), Post-partum ... comparison #diagnosis #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... signs or symptoms (eg ... #Algorithm #Differential ... #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Increased Requirement (e.g ... • Small Bowel Disorder ... #elevatedMCV #Differential ... Algorithm #Causes #Hematology