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diagnosis causes management abnormal bleeding bruising coagulation erythematosus lupus prolonged sle activation algorithm arthritis cell cerebritis classification cns cryofibrinogenemia cryoglobulinemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... selected cases: INR/PT ... , aPTT(liver disease ... #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... • Reduced liver ... associated with systemic ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... associated with systemic ... Causes #diagnosis #differential ... #hematology #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Bleeding / Bruising - Differential ... Sequestration Disordered ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... Algorithm #Causes #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE) Clinical ... , Seizure disorders ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... deficiency • Liver ... liver failure, ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Diagnosis #Management #Hematology ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... - (Ischemia, ... (e.g. systemic ... classification #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
be performed PT ... tissue damage from ischemia ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulinemia Associated Disorders ... processes: • Systemic ... limb and bowel ischemia ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
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