33 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... ongoing ↑ LFTs or symptoms ... #differential #Diagnosis ... #algorithm #gastroenterology ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... for alternative causes ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
- Differential Diagnosis ... Trauma: Shock liver ... • Iatrogenic: DILI ... See Updated Schema ... #causes #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... Causes of Acute ... • Iatrogenic: DILI ... #algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
postpartum): • Initial symptoms ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... ) Differential Diagnosis ... #Pregnancy #hepatology
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
- Differential Diagnosis ... Algorithm True ... /signs, bidirectional ... • Transient Ischemic ... #Algorithm #Causes
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Algorithm Symptoms ... quadrant discomfort Signs ... Associated history: Symptoms ... Liver biopsy findings ... #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Algorithm Severe ... Drugs/Toxins • Ischemia ... Others #LFTs #Hepatology ... #Algorithm #Causes
Anterior ischemic optic neuropathy (AION) - Recognition of giant cell arteritis (GCA)

1) Is visual loss caused
Anterior ischemic ... Is visual loss caused ... Doppler US : halo sign ... #Rheumatology #Ophthalmology ... #Diagnosis #Algorithm
Diplopia - Double Vision - Differential Diagnosis Algorithm
Clinical Pearls:
 • Diplopia is almost always binocular.
 •
Algorithm Clinical ... • Neurologic symptoms ... a mass as the cause ... #Algorithm #Causes ... #Ophthalmology