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diagnosis hepatology lfts injury hepatitis elevated abnormal aflp aion anteriorischemicopticneuropathy ascites chemistry druginduced fatty function gca giantcellarteritis hepatocellular hypertension interpretation
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Hepatopathy • Acute ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology ... #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
- Differential ... Trauma: Shock liver ... • Iatrogenic: DILI ... #Diagnosis #causes ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Ichemic hepatitis ... #Causes #Differential ... #Hepatology #Diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... for Transaminitis ... Drugs, Viral, Ischemia
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Vascular Causes ... of Acute Liver ... • Iatrogenic: DILI
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury Differential ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
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