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diagnosis hematology differential management vasculitis classification sle table anemia arterial bone cerebritis cns cryofibrinogenemia cryoglobulinemia cryoglobulins druginduced embolism erythematosus extravascular
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... ischemia and/or ... cyclophosphamide • Ischemic ... CNS #neurology #rheumatology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
from Myocardial Ischemia ... from myocardial ischemia ... associated with rheumatologic ... life-threatening causes ... #Presentation #comparison
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 Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... • Mechanism: ischemic ... Pain #SickleCell #Disease ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... - Strong Medicine ... Extravascular #Causes ... differential #diagnosis #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... Evolution: Chronic disease ... #sle #comparison ... #table #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Related conditions: Stroke ... limb and bowel ischemia ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... tract, and often causes ... Kidneys: glomerular ischemia ... Palpable purpura: strong ... differential #diagnosis #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... decrease in most cases ... tissue damage from ischemia ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis: • Purpura, ischemic ... and mesenteric ischemia ... Non-glomerular ischemia ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Nephrotic Syndrome, Ischemic ... considered in all cases ... coagulation and other causes ... pathophysiology #hematology
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