14 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... ischemia and/or ... cyclophosphamide • Ischemic ... #rheumatology #
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... Pathophysiology of disease ... the efflux of potassium ... organs leading to ischemia ... Complications #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... • Cholestatic disease ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... • Mechanism: ischemic ... Pain #SickleCell #Disease ... #hematology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
burns, trauma - Ischemic ... • Addison’s disease ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
burns, trauma - Ischemic ... • Addison’s disease ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Myeloproliferative disease ... Nephrotic Syndrome, Ischemic ... considered in all cases ... coagulation and other causes ... pathophysiology #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
with autoimmune diseases ... limb and bowel ischemia ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... decrease in most cases ... tissue damage from ischemia ... hematuria (without casts ... Diagnosis #Workup #Hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura, ischemic ... and mesenteric ischemia ... Non-glomerular ischemia ... tract, and often causes ... Differential #Diagnosis #Rheumatology