22 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... • NAFLD • Cirrhosis ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... Algorithm #diagnosis #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Ichemic hepatitis ... - Drug-Induced liver ... #Differential #Hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminases / Transaminitis ... Trauma: Shock liver ... See Updated Schema ... Differential #Diagnosis #causes ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Portal Vein Thrombosis (PVT) Treatment Algorithm
 - If concern for ischemic: anti-coag+multidisciplinary care
 - W/o cirrhosis+recent
If concern for ischemic ... multidisciplinary care - W/o cirrhosis ... anti-thrombotic tx - Cirrhosis ... : case-by-cased ... management #Algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... for alternative causes ... disease, Hepatic ischaemia ... Diagnosis #Algorithm #hepatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
, - regional ischemia ... perfusion - shock->treatments ... - regional ischemia ... before beginning treatment ... - Mesenteric ischemia