31 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver Disease ... : Primary Biliary ... Cirrhosis vs Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Algorithm Symptoms ... #PBC #Primary ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... relative with PBC ... #Cirrhosis #Pathophysiology ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Cirrhosis (PBC) ... Pathophysiology ... Signs and Symptoms ... diagnosis #workup #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Drugs, Viral, Ischemia ... Ducts - PBC ... , PSC, Alcoholic ... Congenital, Others, Cirrhosis ... Algorithm #diagnosis #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury - Ichemic ... hepatitis - Wilson disease ... Hemochromatosis - Primary ... #Differential #Hepatology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... - Pathophysiology ... organs leading to ischemia ... #Pathophysiology ... Complications #Hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Most common symptoms ... - Bone symptoms ... - Drugs - Primary ... biliary Cholangitis (PBC ... Diagnosis #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... • Cholestatic disease ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... biliary cirrhosis ... (PBC), or with ... systemic diseases ... Sjogrens #Syndrome #Pathophysiology