22 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... 5-10x normal - Chronic ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... Liver #Injury #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic ... or chronic hepatitis ... Fitz-Hugh-Curtis syndrome ... Differential #Diagnosis #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
• NAFLD • Cirrhosis ... • Chronic Viral ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis
High albumin gradient (>1.1 g/dl):
 - Cirrhosis	
 - Alcoholic
>1.1 g/dl): - Cirrhosis ... without cirrhosis ... - Nephrotic syndrome ... associated with bowel ischemia ... Differential #Diagnosis #hepatology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
Management of Cirrhosis ... 8g per liter of ascites ... • Hepatorenal syndrome ... Indications #Management #Cirrhosis ... #treatment #hepatology
Causes of Biliary Dilatation - Differential Diagnosis
 • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy
 •
sludge), Mirizzi's syndrome ... Inflammatory: Chronic ... Parasitic infection, Ischaemic ... differential #diagnosis #hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... AKI, acute limb ischemia ... organ damage • Treatment ... diagnosis #management #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... disorder (e.g. ascites ... ), Chronic hepatitis ... Diagnosis #Algorithm #hepatology
Portal Vein Thrombosis (PVT) Treatment Algorithm
 - If concern for ischemic: anti-coag+multidisciplinary care
 - W/o cirrhosis+recent
Thrombosis (PVT) Treatment ... If concern for ischemic ... multidisciplinary care - W/o cirrhosis ... anti-thrombotic tx - Cirrhosis ... management #Algorithm #hepatology
Hepatorenal Syndrome - Diagnosis and Management Summary
Who gets HRS?
 • Decompensated cirrhosis
 • Typically with existing
Hepatorenal Syndrome ... Decompensated cirrhosis ... with existing ascites ... circulatory overload, CV ischemia ... #Hepatorenal #Syndrome