36 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... 5-10x normal - Chronic ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #Injury #hepatology
Signs of Chronic Liver Disease ( Cirrhosis )

#Diagnosis #Cirrhosis #Signs #Symptoms #Hepatology
Signs of Chronic ... Liver Disease ( ... Cirrhosis ) ... #Signs #Symptoms ... #Hepatology
Cirrhosis leading to Chronic Liver Failure - Clinical Signs and Symptoms

#Cirrhosis #LiverFailure #Signs #Symptoms #PhysicalExam #Findings
Cirrhosis leading ... to Chronic Liver ... Clinical Signs and Symptoms ... #Cirrhosis # ... Findings #Diagnosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Differential Diagnosis Chronic ... liver disease ( ... cirrhosis or chronic ... Fitz-Hugh-Curtis syndrome ... Differential #Diagnosis #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... Nonalcoholic fatty liver ... heart failure (chronic ... disease (Budd-Chiari syndrome ... #Differential #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... months without treatment ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
Management of Cirrhosis ... ) - 8g per liter ... • Hepatorenal syndrome ... Indications #Management #Cirrhosis ... #treatment #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... Diagnosis #Algorithm #hepatology