42 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... 20x normal - Acute ... AST:ALT = 1 - Ischemia ... , Ischemic Necrosis ... #hepatology #LFTs
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... Drug-Induced liver injury ... #Differential #Hepatology ... #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Hepatopathy • Acute ... Viral Hepatitis ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... #hepatology #transaminitis
Hepatitis B Virus Serology and Interpretation
HBsAg - Anti-HBs - Anti-HBc - HBeAg - Anti-HBe
 - Acute
- Anti-HBe - Acute ... of cases) - Acute ... #HBV #Serology ... Interpretation #diagnosis ... #laboratory #hepatology
Interpretation of Hepatitis B Serologies 
HBsAg - HBcAb (total) - HBcAb (IgM) - HBsAb
Susceptible to HBV
Immune
Interpretation of Hepatitis ... to HBV vaccine Acute ... infection vs Resolving acute ... HepBVirus #Serologies #serology ... #diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... • Infections: Hepatitis ... • Vascular: Ischemic ... #hepatology #algorithm ... Transaminitis #LFTs #hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Drug-Induced Liver Injury ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... hepatitisIschemic ... hepatitisAcute ... distinguishes ischemic ... • Demand ischemia
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... Sophia_Hayes_MD #Liver #Injury ... #Differential #Diagnosis ... #algorithm #hepatology