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differential hematology management causes algorithm rheumatology cardiology injury lfts pain signs transaminitis oncology abdominal aflp comparison infectiousdiseases obstetrics pathophysiology pregnancy
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... 20x normal - Acute ... AST:ALT = 1 - Ischemia ... , Ischemic Necrosis ... #Injury #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... - Drug-Induced liver ... #Differential #Hepatology ... #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
- Differential Diagnosis ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic ... #hepatology #transaminitis
Mesenteric Ischemia - Differential Diagnostic Schema Chronic: ASCVD, Venous, Vasculitides 5% (PAN, [E]GPA, IgA, MPA) Acute - Venous
Mesenteric Ischemia ... GPA, IgA, MPA) Acute ... inflammation (e.g ... Antiphospholipid syndrome ... #Mesenteric #Ischemia
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... hepatitis • Ischemic ... hepatitis • Acute ... distinguishes ischemic ... injury • Demand ischemia
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Diagnosis Hepatocellular ... obstruction, HELLP Syndrome ... #Differential #Diagnosis ... #algorithm #hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... factors - Possible ischemic ... hepatitis (e.g. ... ) or metabolic liver ... #Diagnosis #Hepatology
Clinical manifestations of acute liver failure Brain: Hepatic encephalopathy, Cerebral edema, Intracranial hypertension,
liver failure ... abnormalities Liver ... Anemia, Thrombocytopenia ... #Signs #Symptoms ... #Diagnosis
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... factors • Possible ischemic ... hepatitis (e.g. ... ) or metabolic liver ... #hepatology #criteria
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