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Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... 20x normal - Acute ... AST:ALT = 1 - Ischemia ... , Ischemic Necrosis ... Liver #Injury #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe Acute ... Liver Injury - Ichemic ... hepatitis - Acute ... - Wilson disease ... #Differential #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Chronic Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Metabolic: Wilson Disease ... • Autoimmune hepatitis ... See Updated Schema ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Injury: • Early acute ... hepatitis • Ischemic ... hepatitis • Acute ... distinguishes ischemic ... injury • Demand ischemia
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... , Acute biliary ... obstruction, HELLP Syndrome ... , Celiac Disease ... #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... • Cholestatic disease ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... underlying liver disease ... (DILI) Viral Hepatitis ... Procedures Management ... Failure #Cirrhosis #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... HELLP, Celiac disease ... Differential #Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
of Autoimmune Hepatitis ... factors - Possible ischemic ... hepatitis (e.g. ... (Wilson disease ... #Diagnosis #Hepatology
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