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causes lfts transaminitis management acute dili aclf ascites biliary chemistry cholangitis conjugated direct drug druginduced failure function hbv hepatitisb hepatocellular
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Diagnosis Framework ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... transaminitis #differential ... #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... : < 1 • Cirrhosis ... #injury #hepatitis ... diagnosis #algorithm ... #hepatology
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Diagnosis Chronic ... liver disease ( ... cirrhosis or chronic ... hepatitis) - 80% ... #Diagnosis #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Nonalcoholic fatty liver ... heart failure (chronic ... 14 percent) #Diagnosis ... #Differential # ... Hepatology #Cirrhosis
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 Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
: < 1 • Cirrhosis ... : > 3 • Chronic ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Primary Biliary Cirrhosis ... #Diagnosis #Algorithm ... #Causes #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... #differential # ... #algorithm #gastroenterology ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #Algorithm #Diagnosis ... Management #Treatment #Hepatology
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