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transaminitis aclf acute chemistry dili drug failure function idiosyncratic induced interpretation patterns rvalue tests
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Differential Diagnosis ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... #differential # ... diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... - ongoing ↑ LFTs ... Diagnosis #Management ... #algorithm #gastroenterology ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... : < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... : < 1 • Cirrhosis ... #injury #hepatitis ... diagnosis #algorithm ... #hepatology
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