21 results
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
syndrome Typical ... atlanto-axial instability ... #Downs #Syndrome ... #PhysicalExam # ... Features #Signs
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... findings • Anterior Knee ... Patellofemoral #Syndrome ... #pathophysiology ... #diagnosis #signs
Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
 • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin Syndrome ... normalize vital signs ... illness with VS instability ... ucsdim #Serotonin #Syndrome ... #Management #treatment
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Ehlers-Danlos syndrome ... • Down, Turner ... , Marfan syndromes ... • Rizutti's Sign ... #Keratoconus #pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... hyperviscosity syndrome ... WBC >100k, + lab signs ... : • Pathophysiology
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... pain radiating down ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
mutations - Down ... syndrome (amyloid ... chromosome 21) Signs ... AlzheimersDisease #Dementia #pathophysiology ... geriatrics #diagnosis #signs
Kussmaul's Sign on Neck Physical Examination

Elderly woman with a history of myocardial revascularization surgery is hospitalized
Kussmaul's Sign ... heart failure syndrome ... The Kussmaul sign ... #PhysicalExam # ... Video #Clinical #JVP
Rare Causes of Abdominal Pain
 • Hereditary Angioneurotic Edema - Recurrent visceral that may by swelling
arcuate ligament syndrome ... mesenteric artery syndrome ... patient is in the knee-to-chest ... the prone (face down ... Positive Carnett's sign
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
: Pathogenesis and ... nephrotic/nephritic syndrome ... arthritis (especially knees ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs