38 results
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Diagnosis Algorithm ... Dilatation on Ultrasound ... Gallstones • Biliary ... Primary Sclerosing Cholangitis
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary ... Primary Sclerosing Cholangitis
Right Upper Quadrant Pain
Liver:
 - Infectious: Acute viral hepatitis, Liver abscess
 - Non-infectious: hepatitis (Alcohol, Medications),
Quadrant Pain Liver ... viral hepatitis, Liver ... Budd-Chiari syndrome Biliary ... "ascending cholangitis ... "biliary colic")
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... hepatitis - Acute biliary ... - Drug-Induced liver ... Hemochromatosis - Primary biliary ... cholangitis
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... postoperative jaundice ... mononucleosis, cholangitis ... duct, sclerosing cholangitis ... neoplasms #Jaundice
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... and Biliary Diseases ... erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... Bruising, Edema #biliary
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Bacterial Cholangitis ... Primary Sclerosing Cholangitis ... • Primary Biliary
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Benign/malignant biliary ... obstruction, Primary biliary ... cholangitis, Primary ... sclerosing cholangitis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... cholestasis → Cirrhosis/Liver ... hyperpigmentation • Jaundice ... No extrahepatic biliary ... or higher • Liver
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Cholangitis (PBC ... PSC - Other biliary