14 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism - Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... Bilirubin #Metabolism #Pathophysiology ... #hepatology #Liver
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Pre-Hepatic - Unconjugated ... II) Hepatic - Conjugated ... Cholangitis #Jaundice ... Algorithm #Causes #Hepatology
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... bilirubin, and conjugated ... Biochemistry #Metabolism #pathophysiology ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... • Increase in conjugated ... Congenital #bilirubin #hepatology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
for transporting unconjugated ... Decreased MRP2 - Conjugated ... Decreased OATP1B - Conjugated ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
cytochromes) • Unconjugated ... MRP2 transports conjugated ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Amy Chung, MD, MSc ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Bilirubin metabolism and pathophysiology of jaundice 

#Bilirubin #metabolism #pathophysiology #jaundice #hepatology
metabolism and pathophysiology ... of jaundice # ... Bilirubin #metabolism #pathophysiology ... #jaundice #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... (DIC, ascites, jaundice ... Liver #Pregnancy #hepatology ... diagnosis #management #pathophysiology