17 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated ... BilirubinUnconjugated ... #Metabolism #Pathophysiology
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Biochemistry and Metabolism ... Conjugation → Conjugated ... , and conjugated ... #Biochemistry #Metabolism ... #pathophysiology
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... drug reactions) Conjugated ... conjugates (eg, ... postoperative jaundice ... neoplasms #Jaundice
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... an increase in conjugated ... • Increase in conjugated
Bilirubin metabolism and pathophysiology of jaundice 

#Bilirubin #metabolism #pathophysiology #jaundice #hepatology
Bilirubin metabolism ... and pathophysiology ... of jaundice # ... Bilirubin #metabolism ... #pathophysiology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Metabolism AST ... metabolism: • ... MRP2 transports conjugated ... Tests #Laboratory #Metabolism ... #Hepatology #Pathophysiology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
pathways involved in bilirubin ... bilirubin into ... Decreased MRP2 - Conjugated ... Decreased OATP1B - Conjugated ... Hyperbilirubinemia #pathophysiology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Reticulocytes, Increased Unconjugated ... Bilirubin, Spherocytes ... Disorder • RBC Metabolism
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
) • Onset of jaundice ... before the onset of jaundice ... • Serum total bilirubin ... within 7 days) or metabolic ... days of onset of jaundice