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Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential ... khudhur_moh #jaundice ... #gastroenterology
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... , Rotor syndrome ... hepatocyte damage (eg, hepatitis ... postoperative jaundice ... neoplasms #Jaundice
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
diagnosis of Alcoholic Hepatitis ... ) • Onset of jaundice ... before the onset of jaundice ... Possible ischemic hepatitis ... days of onset of jaundice
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... before the onset of jaundice ... Possible ischemic hepatitis ... days of onset of jaundice
Inherited Colorectal Cancer (CRS) Syndromes
Adenomatous Polyposis Syndromes:
 • Familial Adenomatous Polyposis (FAP), Attenuated FAP (AFAP), MUTYH
Colorectal Cancer (CRS) Syndromes ... Adenomatous Polyposis Syndromes ... Urinary → Lynch Syndrome ... Peutz-Jeghers Syndrome ... diagnosis #management #gastroenterology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... Cholangitis #Jaundice
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
hyperbilirubinemia syndrome ... breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... hepatology #diagnosis #gastroenterology
Irritable Bowel Syndrome (IBS) in Pregnancy
 - Pathophysiology
 - Pharmacotherapy
 - Nonpharmacological Treatment

Emory Gastroenterology and Hepatology
Irritable Bowel Syndrome ... Treatment Emory Gastroenterology ... Irritable #Bowel #Syndrome ... Pregnancy #diagnosis #gastroenterology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
• Budd-Chiari Syndrome ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Autoimmune Hepatitis ... • Drug Induced Hepatitis
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... • Autoimmune hepatitis ... Transaminases #hepatitis