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diagnosis differential hematology comparison management aflp antibodies associations autoantibodies celiac coagulation common conditions cvid deficiencies deficiency diseases extrarticular gap globulin
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... Dermatomyositis Anti-LKM (liver ... ) - Autoimmune hepatitis ... #diagnosis #table ... #rheumatology #
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g. celiac disease ... ) • Advanced Liver ... Disease - Alcohol ... , Viral hepatitis ... Deficiencies #Summary #table
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Pruritus, Mild jaundice ... necrosis HELLP Syndrome ... #Disease #Pregnancy ... hepatology #obstetrics #hepatitis
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
- Gout • Jaundice ... - Hepatitis ... GI - Felty syndrome ... • Felty's syndrome ... differential #diagnosis #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and hepatitis ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Celiac Disease - Clinical Manifestations Gastrointestinal Manifestations: • Diarrhea, Loose stools, Dyspepsia, Flatulence, Chronic abdominal pain,
Celiac Disease - ... Flatulence, Chronic abdominal ... puberty • Elevated liver ... transaminases, Hepatitis ... symptoms #diagnosis #gastroenterology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... SLE • Mikulicz syndrome ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... #Rheumatology #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... HBV, EBV, VZV, hepatitis ... Sarcoidosis) • Liver ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis
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