12 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Cirrhosis • Chronic ... Viral Hepatitis ... : • Genetic/Metabolic ... Differential #Diagnosis #hepatology ... #transaminitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
> 2 • NASH, Chronic ... viral hepatitis ... injury: > 3 • Chronic ... #differential #Hepatology ... #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... 5-10x normal - Chronic ... NASH, Genetic / Metabolic ... #Injury #hepatology ... #LFTs #transaminitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... free fatty acid metabolism ... (DIC, ascites, jaundice ... Diagnosis: Viral Hepatitis ... Pregnancy #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
- Onset of jaundice ... within 7 days) or metabolic ... liver disease ( ... Possible drug-induced liver ... #Diagnosis #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
) • Onset of jaundice ... within 7 days) or metabolic ... liver disease ( ... Possible drug-induced liver ... #AH #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Metabolic/Hereditary ... > 2 • NASH, Chronic ... viral hepatitis ... injury: > 3 • Chronic ... diagnosis #algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... inflammation (decr ALT ... Chronic Hepatitis ... Diagnosis #Management #Treatment ... #Hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... - Symptoms of chronic ... hepatocellular pattern of liver ... regarding need for treatment ... Diagnosis #Management #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... hyperpigmentation • Jaundice ... obstruction • ALP ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology