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diagnosis management leukemia anesthesia anesthesiology checklist chronic hodgkins intraoperative lymphocytic lymphoma mgus monoclonal signs algorithm anaesthetic cancer central classification comparison
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... • Age: 60-80 Clonal ... ) CLL Symptoms: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... Orange or Hep C Clinical ... with no early symptoms ... Leukemia #diagnosis #workup ... #oncology #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... Reed Sternberg cell ... based on: - Cell ... type (B cell, T ... NonHodgkins #comparison #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
1 or more: • Clonal ... marrow plasma cell ... , B and T cell lymphoproliferative ... MGUS #diagnosis #hematology ... #oncology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Management Summary Clinical ... disease 48% (light chain ... marrow plasma cells ... cell in bone marrow ... Diagnosis #Management #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... cytometry → >500/uL clonal ... immunophenotype Clinical ... Transformation to large cell ... uw_IMresidency #CLL
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
constitutional symptoms ... type) < 3 g/dL • Clonal ... to the plasma cell ... proliferative disorder • Clonal ... #diagnosis #oncology
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
When to look for clonal ... ) - Clinical symptoms ... Cytopenia, Other cell ... Diagnosis #Signs #Hematology ... #Workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Pathogenesis and clinical ... (inflammation blocks ... and destroying thin ... ) Stage 4: Cell ... pathophysiology #signs #symptoms
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