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diagnosis hematology chronic hodgkins lymphocytic management cell classification comparison differential emergencies erythematosus gammopathy lupus mgrs monoclonal nonhodgkins oncologic plasmacytoma renal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... • Age: 60-80 Clonal ... (SLL) CLL Symptoms ... lymphoma #Leukemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... lymphoproliferative ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
cytometry → >500/uL clonal ... immunophenotype Clinical ... lymphoma (Richter ... #oncology #hematology ... #hemeonc #diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... - B symptoms ... involved) • No leukemic ... Noncontiguous spread • Clinical ... NonHodgkins #comparison #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... - Clinical Presentation ... ingestion • B symptoms ... Workup: • Full ... classification #hematology #oncology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
B-cell or plasma ... smoldering myeloma/lymphoma ... Clinical Clues: ... Diagnostic Workup ... extramedullary disease or lymphoproliferative
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... lymphoma • Evans ... • Autoimmune lymphoproliferative ... Induced Lupus: • Symptoms ... and leukemia •
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... Usually myeloid leukemias ... ± tocilizumab; call ... #HemeOnc #Diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... biopsy negative or clonal ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology ... #Diagnosis #Workup
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