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diagnosis hematology management causes syndrome algorithm lymphocytic mds myelodysplastic anemia apml behcet cancer comparison differentiation disease eosinophilia erythematosus hemeonc hodgkins
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... ALL Symptoms: ... • Age: 60-80 Clonal ... ) CLL Symptoms: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... aplasia • ITP ... #CLL #Chronic ... diagnosis #workup #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... cytometry → >500/uL clonal ... #Leukemia #oncology ... #hematology #hemeonc
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... transformation to acute leukemia ... Allogeneic stem cell ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... virus (EBV) • Leukemia ... • Improve the symptoms ... #Anemia #oncology ... #hematology #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... hemorrhage) • Chronic ... Myelodysplastic syndrome ... myeloid leukemia ... (CML) - Dr.
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Eosinophilia - Differential ... Primary: - CML ... Hypereosinophilic Syndrome ... - Chronic Eosinophilic ... Leukemia Dr.
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... Cell Leukemia ... #oncology
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