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diagnosis hematology differential causes chronic cll management aplastic cancer dermatology diffuse generalized hemeonc lad leukocytosis lymphadenopathy mds myelodysplasia myelodysplastic primary
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... • Most common leukemia ... cytometry → >500/uL clonal ... marrow failure with anemia ... #Leukemia #oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Neoplastic: - Leukemia ... Lymphoblastic Leukemia ... includes Blasts) - Leukemia ... Leukemia (CBC with ... Causes #Hematology #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... - infiltrates (anemia ... Leukemia): • Lymphocytes ... • Age: 60-80 Clonal ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary ... • Most common leukemia ... with no early symptoms ... • Neutropenia, anemia ... #workup #oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Differential Diagnosis Algorithm ... malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... hematology #WBC #Leukemoid
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Psoriasis • Lichen Planus ... renal failure/uremia ... • Lymphoma • Leukemia ... Differential #Diagnosis #Algorithm
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... virus (EBV) • Leukemia ... • Improve the symptoms ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... diagnosis #hematology #oncology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
current treatment algorithm ... cytopenias, and clonal ... with a risk of clonal ... acute myeloid leukemia ... disease tolerate anemia
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