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diagnosis hematology algorithm differential management chronic classification cll lymphoma workup aplastic cancer causes cell comparison diffuse disorders erythematosus gammopathy hemeonc
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphocytes) ... - Monoclonal Lymphocytes ... Biopsy • Non-Hodgkin's ... Biopsy • Hodgkin's ... Causes #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... cytometry → >500/uL clonal ... of anemia or thrombocytopenia ... marrow failure with anemia ... #Leukemia #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... with no early symptoms ... • Neutropenia, anemia ... , Hodgkin’s lymphoma ... #workup #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... - infiltrates (anemia ... Leukemia): • Lymphocytes ... • Age: 60-80 Clonal ... #Hematology #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... ingestion • B symptoms ... HL (MCHL) - Lymphocyte ... classification #hematology #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- B symptoms ... involved) • No leukemic ... Nodal disease: B symptoms ... Diagnosis of B-Symptoms ... NonHodgkins #comparison #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm Hodgkin ... Rich, Lymphocyte ... Depletion Non-Hodgkin ... pattern of spread, B symptoms ... Treated Like Acute Leukemias
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... virus (EBV) • Leukemia ... • Improve the symptoms ... #oncology #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
No evidence of anemia ... constitutional symptoms ... type) < 3 g/dL • Clonal ... insufficiency, Anemia ... hematology #diagnosis #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... diagnosis #hematology #oncology
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